Complementary and Alternative Medicine (CAMs) and Pharmacogenomics

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Topic: Pharmacogenomics in Primary Care

Explain one of the following statements in your own words. Give an example of implications for you as the prescribing primary care provider.

1. Carbamazepine has a black box warning recommending      testing for the HLA-B*1502 allele in patients with Asian ancestry prior to      starting therapy.
2. Testing for CYP2D6 variants prior to starting tamoxifen      for breast cancer.
3. A genetic variation in how the metabolite of the cancer      drug irinotecan SN-38 is inactivated by the body.